The #1 Special Purpose Exam Review

Med-Challenger SPEX

Online SPEX exam review with AMA credits.
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Over 3,400 SPEX-style questions + AMA PRA Category 1 CME Credits™.
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SPEX Exam Review + CME
Up-to-date SPEX Exam Review Questions
3400+ SPEX-style Questions
Detailed Explanations & Rationales
Targeted to FSMB & NBME Exam Blueprint
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Included in all product packages:
Intelligent board exam simulators
Topic-based review options
Automatic remediation guidance
Practice & review tutor modes
Custom exam builder
Light & Dark interface themes
Activity dashboards, analytics, and reports
CME claims & certificate management
Single 24/7 online account for all purchases
Weekly CME games with peer leaderboards
Free content updates
Free live US-based customer support
best online board review courses
“The Challenger SPEX review course was extremely thorough. I worked through the whole thing three times in a row and then took about 20 exams. When I had passed five in a row, as I think they suggest, I knew I was ready.”S. Gilbert, MD, JD

Multiple Benefits, Uses & Utilities

Ace the Special Purpose Exam with the #1 Online Special Purpose Exam Review Course.
100% Pass-guaranteed SPEX Exam Review with AMA PRA Category 1 CME Credits™ & MOC Points too!

  • Everything you need to know.
    • FSMB & NBME exam blueprint & SPEX Model-based content
    • Written & peer-reviewed by medical specialists
    • SPEX-style case-based questions
    • Detailed answers and explanations
    • Bite-sized topic-based learning segments
    • Clinical texts and media banks
    • Continually updated
    • Dashboards help you the most out of your assets
  • everything you need to know
  • Risk-free, time-saving exam review.
    • 100% pass-guaranteed SPEX exam review
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    • Exam simulation & topic-based study options
    • Practice & review tutor modes
    • Custom exam builder
    • 99.8% pass-rate
  • Med-Challenger SPEX exam review course
  • Satisfy MOC & CME requirements
    • Earn AMA PRA Category 1 CME Credits
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Content & Questions

Med-Challenger offers the most exam-focused content and exam review questions.

Over 230
Topics Covered
Over 3400
spex-style questions

Blueprint-based Exam Simulation

NBME publishes a content blueprint of the material that will appear on the exam.

This is how we determine which material appears in exam simulations.

General Principles
Disorders of Blood
Disorders of the Nervous System/Special Senses
Mental Disorders
Disorders of the Skin
Disorders of the Musculoskeletal System
Disorders of the Respiratory System
Cardiovascular Disorders
Gastrointestinal Disorders
Renal and Urinary Disorders
Disorders of the Male Reproductive System
Female Reproductive System and Pregnancy
Disorders of the Endocrine System
Immunologic Disorders

Table of Contents

Everything you need to know for your Special Purpose Exam.

Abdominal Pain
Acute Pelvic Pain in Women
Acute Vaginal Bleeding
Back Pain
Chest Pain
Depressed Consciousness and Coma
Dizziness and Vertigo
Fever in the Adult Patient
Gastrointestinal Bleeding
Headache: Initial Approach
Nausea and Vomiting
Seizures: Initial Approach
Disseminated Intravascular Coagulation
Hematologic Malignancies
Management of Malignant Pain
Pediatric Hematology and Oncology
Sickle Cell Disease
Transfusion Medicine (Principles and Complications)
Central Nervous System Disorders: Delirium and Dementia
Central Nervous System Disorders: Demyelinating/Inflammatory Diseases
Central Nervous System Disorders: Diseases of Movement Control
Central Nervous System Disorders: Seizures
Central Nervous System Disorders: Spinal Cord Syndromes
Central Nervous System Infections
Cerebrovascular Accidents: Epidemiology and Presentation
Cerebrovascular Accidents: Initial Work-up
Cerebrovascular Accidents: Preventive Care
Cerebrovascular Accidents: Treatment
Headache: Cervical Neck Vessels, Subarachnoid, and Venous Emergencies
Headache: Cluster, Migraine, and Tension
Headache: Less Common Etiologies
Neurologic Assessment
Pediatric Neurologic Disorders
Peripheral Nervous System Disorders: Neuromuscular Junction Disease
Peripheral Nervous System Disorders: Neuropathies
Selected Cranial Nerve Disorders
Eye: Assessment
Eye: Glaucoma
Eye: Inflammation and Infection
Eye: Pharmacology
Eye: Vascular Disorders
Neoplasms of the Head and Neck
Nose: Infection and Inflammation
Oral Cavity: Medical Disorders
Otologic Infections
Otologic Signs, Symptoms, Presentations
Pediatric Eye, Ear, Nose, and Throat Disorders
Throat and Soft Tissue Neck: Medical Disorders
Affective Disorders
Anxiety Disorders
Dissociative Disorders
Eating Disorders
Factitious Disorders and Malingering
Obsessive-Compulsive Disorder
Pediatric Psychiatric Disorders
Personality Disorders
Psychiatric Assessment
Psychological Factors Affecting Medical Disorders
Somatoform Disorders
Suicidal Behavior
Thought Disorders
Cancers of the Skin
Cutaneous Infections
Dermatitis (non-infectious)
Maculopapular Lesions
Papular/Nodular Lesions
Pediatric Dermatology
Ulcerative Lesions
Vesicular/Bullous Lesions
Bone and Joint Infections
Bone Tumors
Crystal-induced Arthropathy
Deep Soft Tissue Infections
Disorders of Muscles
Infectious, Inflammatory, and Reactive Arthritis
Neck and Back Pain
Pediatric Rheumatology and Musculoskeletal Disorders
Rheumatoid Arthritis
Sports Injuries/Trauma
Systemic Lupus Erythematosus
Systemic Sclerosis
Acute Upper Airway Disorders (Incl. Peds.)
Asthma and other Obstructive Lung Disease
Interstitial Lung Disease
Lower Respiratory Tract Infections
Lung Cancer
Occupational and Environmental Lung Disease
Pleural Disease
Pulmonary Vascular Disease
Sleep Medicine
Upper Respiratory Tract Infections
Congenital Heart Disease in the Adult
Congestive Heart Failure
Dysrhythmias/Conduction Defects
Ischemic Heart Disease
Myocardial Disease
Pericardial Disease
Valvular Heart Disease
Vascular Disease
Pediatric Cardiovascular Disorders
Biliary Tract Disease
Colonic and Anorectal Disease
Esophageal Disorders
Foodborne and Waterborne Diseases
Gastrointestinal or Hepatic Cancer
Liver Disease
Obstruction, Ischemia, Perforation, Peritonitis
Pancreatic Disease
Pediatric Gastrointestinal Disorders
Small Intestinal Disease
Stomach or Duodenum
Undiagnosed Gastrointestinal Hemorrhage
Acute Renal Failure
Chronic Kidney Disease
Glomerular Disorders
Nephropathy, Contrast Induced
Pediatric Nephrology and Urology
Prostate Disorders
Renal Failure: Chronic
Renal Transplantation
Urinary Incontinence
Urinary Retention
Urinary Tract Infections
Urological Assessment
Urological Cancer
Water and Electrolyte Balance
Penile Disorders
Prostate Disorders
Sexually Transmitted Infections: Male
Testicular Disorders
Acute Complications of Pregnancy
Breast Cancer
Chronic Medical Illness During Pregnancy
General Approach to the Pregnant Patient
Gynecologic Cancer
Gynecological Assessment
Menopause and Hormone Therapy
Screening and Regular Health Care in Adult Women
Sexual Assault
Sexually Transmitted Infections: Female Genital Lesions
Sexually Transmitted Infections: Vaginal Discharge
Adrenal Disorders
Clinical Context: Alcoholic and Lactic Acidosis
Diabetes Mellitus
Disorders of Calcium Metabolism and Bone
Endocrine Disorders: Diabetic Ketoacidosis
Endocrine Disorders: Hyperosmolar Hyperglycemic State
Lipid Disorders
Pediatric Endocrine Disorders
Thyroid Disorders
Auto-Immune Collagen Vascular Disorders
Drug Allergy
Food Allergy
Hypersensitivity Reactions
Pediatric Allergy and Immunology
Primary Immunodeficiency Disorders
The Immunocompromised/Solid-Organ Transplant Patient
Bacterial Infections: Diphtheria, Pertussis, Tetanus
Bacterial Infections: Meningococcemia, Pneumococcemia
Bacterial Infections: MRSA, VRE, ESBL
Bacterial Infections: Tuberculosis
Parasitic Infections
Pediatric Infectious Diseases
Sepsis Syndromes
Systemic Fungal Infections
Tick-Borne Illnesses
Viral Infections: Hantavirus
Viral Infections: HIV and AIDS
Viral Infections: Influenza, Mononucleosis, Herpes
Viral Infections: Rabies
Childhood Immunizations
Child Safety
Development Milestones
Disease Prevention
Failure to Thrive
Female Pubertal Development
Gynecologic Healthcare
Male Pubertal Development
Normal Growth
Periodic Health Examination/Screening
Pregnancy and Contraception
Self-Identity and Family Influence
Sexuality and Emotional Development
Sexually Transmitted Infections
Geriatrics: Assessment
Geriatrics: Depression
Geriatrics: Falls
Geriatrics: Gait Impairment
Geriatrics: Medical Conditions
Geriatrics: Pharmacotherapy
Geriatrics: Special Problems of the Elderly
Geriatrics: Urinary Incontinence
Airway: Adult
Airway: Pediatric
Breathing: Ventilatory Support (Adult/Pediatrics)
Environmental Disorders
Perioperative Care
Postoperative Complications
Procedural Sedation: Adult
Resuscitation: Adult Cardiac
Resuscitation: Brain (After Cardiac Arrest)
Resuscitation: Neonatal
Resuscitation: Pediatric
Resuscitation: Shock
Resuscitation: Trauma
Toxicologic Disorders
Traumatic Disorders
Wound Management
Diet and Prevention
Exercise and Prevention
Cancer Prevention and Screening
Prevention of Cardiovascular Disease
Prevention of Infectious Disease
Patient Safety
Medical Error Prevention
End-of-Life Care

Expert Contributors

Written & continually maintained by board-certified, practicing medical professionals.

Continually Updated
All content is continually maintained by clinical expert peer-review.

Chief Editors:

Andrea Cecilia Eberly, MD, M.S., FAAEM

Mark E. Deutchman, MD, FAAFP
Professor, Department of Family Medicine
Director, Advanced Training Track
Director, Rural Health Track
University of Colorado Health Sciences Center
Denver, CO

Contributing Authors:

Kathleen K. Aiello, MD, FAAP
Ambler Pediatrics
Ambler, PA

Jennifer Amani, MD
Attending Physician
MBI Occupational Healthcare
Phoenix, AZ

David Auerbach, MD
Attending Physician
Montgomery Radiology Associates
Pottstown, PA

Kelly Bradley-Dodds, MD, FAAP
Program Director, Pediatric Residency
Attending Physician – Pediatrics, Emergency Medicine
Crozer-Chester Medical Center
Upland, PA

Gina Chung, MD
Assistant Professor
Dept. of Internal Medicine, Section of Medical Oncology
Yale University School of Medicine
New Haven, CT

Adam Cohen, MD
Depatment of Oncology
Huntsman Cancer Institute
Salt Lake City, UT

Michael Anthony Darracq, MD, MPH
Emergency Physician
Kaiser Permanente Medical Group, Southern California
San Diego, CA

Michael France, MD
Emergency Room Physician
Memorial Hospital of Carbon County
Rawlins, WY

Arthur Frazzano, MD, FAAFP
Founding Director, Area Health Education Center of RI Network
Director, Division of Health Policy and Advocacy and Associated
Fellowship Program
Associate Professor
Department of Family Medicine
Warren Alpert Medical School
Brown University
Providence, Rhode Island

Gerard Kiernan, MD
Dartmouth Hitchcock Clinic
Keene, NH

Daniel Hayes, MD
Internal Medicine Physician
West Linn, OR

Michael J. Hodgman, MD
Assistant Clinical Professor
SUNY Upstate Medical University
Upstate New York Poison Center
Syracuse, NY

Jassin M. Jouria, Jr., MD
University of Miami
Leonard M. Miller School of Medicine
Miami, FL

Alex Kadner, PhD
Medical Writer/Scientific Consultant, Neuroscience
Ballston Spa, NY

Miguel G. Madariaga, MD, MSc, FACP, DLSHTM
Director, Center for Wound Healing and Hyperbaric Medicine
Physician, Infectious Disease
Doylestown Hospital
Doylestown, Pennsylvania

Jeanna M. Marraffa, Pharm.D., DABAT
Clinical Assistant Professor, Department of Emergency Medicine
SUNY Upstate Medical University
Clinical Toxicologist
Upstate New York Poison Center
Syracuse, NY

Luis A. Mojicar, MD
Center for Living Well Clinic
Orlando, FL

George Smolinksi III, MD
Major, Medical Corps, U.S. Army
Physical Medicine Clinic
Landstuhl Regional Medical Center
Landstuhl, Germany

Richard Snyder, DO
Integrative Medicine Practitioner
LeHigh Valley Nephrology Associates

Rodrigo Tanchanco, MD, FACP
Christiana Medical Group
Newark, DE

Pranav Virmani, MD
Dept. of Emergency Medicine
Inova Loudoun Hospital and Medical Center
Leesburg, VA

Tricia A. Walters, MD
Family Medicine w/ Obstetrics
Wyatt, IN

Mary Wilson, MD
Emergency Medicine Physician
Mercy Hospital
Coon Rapids, MN

Cezary Wojcik, MD, PhD
Deaconess Hospital
Assistant Professor
Dept. of Anatomy & Cell Biology
Indiana University School of Medicine
Evansville, IN

Melissa Wolf, MD
Bozeman Deaconess Women’s Specialists
Bozeman, MT

Sean Wormuth, MD
Emergency Medicine Physician
Kaiser Permanente Medical Center
Vallejo, CA

Built-in MOC & CME Credit Resources

Earn and Claim Credits in a snap.

Earn MOC Points & CME credit while you study. Knock out requirements fast.

Med-Challenger was exactly what I was looking for when searching for SPEX study materials. It was all I needed and more.S. McClellan, MD
  • Score 80% or better on topic-based CME assessments
  • CME earnings will appear in your CME Claims Center
  • Produce PDF CME Certificates (claim credits) instantly
  • PDFs list all topics claimed for hassle-free submission
  • Return anytime to reprint or review historical earnings
Earn Up To
AMA Category 1 CME Credits

CME Accreditation

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of National Association for Continuing Education and Challenger Corporation. The National Association for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

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“The Challenger SPEX review course was extremely thorough. I worked through the whole thing three times in a row and then took about 20 exams. When I had passed five in a row, as I think they suggest, I knew I was ready.”Godefroy Hardy St-Pierre, MD FRCSC

No risk. Pass the SPEX exam, guaranteed.

Satisfy Special Purpose MOC requirements too.

pass the boards guaranteed

For over 25 years.

Over 5000
Special Purpose Practitioners Served
Exam Pass-rate
Avg. Score Improvement
Avg. Study Time Saved

Why is Med-Challenger SPEX the
Best Special Purpose Exam Review?

Our Special Purpose exam review follows the SPEX Model and the exam content outline for the Federation of State Medical Boards (FSMB) and National Board of Medical Examiners’ (NBME) exam specifications. Proven effective for SPEX exam review and Maintenance of Certification (MOC), our SPEX exam, review follows the exam content outline for the Federation of State Medical Boards (FSMB) and National Board of Medical Examiners (NBME) Examination and SPEX Model giving you more than 3400 SPEX exam review practice questions with detailed explanations peer-reviewed by practicing physician educators.

Intelligent, time-saving adaptive learning and prescriptive remediation produces the best review in the shortest time. Dashboards, custom exams, and other career-minded MOC utilities are also included. Our proven SPEX exam review (99.8% pass-rate) follows the SPEX Model and the exam content outline for the Federation of State Medical Boards (FSMB) and National Board of Medical Examiners (NBME).

What’s more, with 266 AMA PRA Category 1 CME Credits built-in™, Med-Challenger’s SPEX exam review Qbank, gives physicians everything needed to ace SPEX exams and fulfill MOC requirements year after year with less time, labor, and worry.

Med-Challenger’s SPEX Exam Review offers the best special purpose review options. Join the over 5,000 special purpose practitioners who’ve used Med-Challenger to outperform on exams – and protect their practice. Try it for free today.

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