COVID-19 Delta Variant 2021 Pre-Guideline Study Findings – Closing the Clinical Knowledge Gap

Andrea Eberly, MD, MS, FAAEMEmergency Medicine, Family Medicine, Guideline Knowledge Check, Internal Medicine, Nurse Practitioner, Nursing RN/PN, Pediatric Emergency Medicine, Pediatric Medicine, Physician Assistant, Urgent Care

COVID-19 Delta Variant 2021 Study Findings

COVID-19 Delta Variant 2021 Pre-Guideline Study Findings - Closing the Clinical Knowledge Gap

Recent information with regards to comparative in vitro protection of either past SARS-CoV-2 infection or vaccination offer against the SARS-CoV-2 Delta variant

Studies are exploring the pros and cons of booster vaccination against COVID-19, especially with the rise of the Delta variant. What did a recent study find with regards to comparative in vitro protection of either past SARS-CoV-2 infection or vaccination offer against the SARS-CoV-2 Delta variant?

Try this COVID-19 review question and find out if you’re following the most current study findings regarding the COVID-19 Delta variant.

A 57-year-old male non-smoker with no past medical history presents with new onset of acute shortness of breath. His only other positive finding is a cough that began 4 months ago.

A work-up shows that he has a mass in his right lung that appears to be obstructing his right upper lobe.

Upon consultation with the pulmonary and cardiothoracic teams, it becomes clear that he will require admission and possibly thoracic surgery.

The patient is fully vaccinated against COVID -19, but is concerned if he is sufficiently protected in the context of lung surgery against the highly prevalent SARS-CoV-2 Delta variant in his area.

Question:

Which of the following statements correctly state in vitro performance of past infection with the original SARS-CoV-2 virus as well as the USA vaccines (Pfizer, Moderna, Johnson & Johnson) against the SARS-CoV-2 Delta variant?

Answer Options:

Natural infection with the original SARS-CoV-2 virus shows superior in vitro protection against the Delta variant, as compared to vaccination with any of the 3 currently available USA vaccines.

Natural infection with the original SARS-CoV-2 virus shows inferior in vitro protection against the Delta variant, as compared to vaccination with any of the 3 currently available USA vaccines.

Natural infection with the original SARS-CoV-2 virus shows similar in vitro effectiveness against the Delta variant as vaccination only with the 2 double-dose USA vaccines.

Natural infection with the original SARS-CoV-2 virus as well as vaccination with any of the 3 currently available USA vaccines all show significantly decreased in vitro effectiveness against the Delta variant as compared to their effectiveness against the original SARS-CoV-2 virus.

See the Answer:

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