Gonorrhea Treatment Guidelines – Closing the Clinical Knowledge Gap

Andrea Eberly, MD, MS, FAAEMClinical Pearls, Emergency Medicine, Family Medicine, Guideline Knowledge Check, Internal Medicine, Nurse Practitioner, Nursing RN/PN, Pediatric Emergency Medicine, Pediatric Medicine, Physician Assistant, Urgent Care

Gonorrhea Treatment Guidelines

Gonorrhea Treatment Guidelines - Closing the Clinical Knowledge Gap

What You Might Not Know About Gonococcal Treatment Guidelines

Gonorrhea treatment is temporarily regulated by 2 sets of CDC guidelines.  In 2020, the Centers for Disease Control and Prevention (CDC) partly updated their gonorrhea treatment guidelines, with the rest to be published at a later date. This creates a temporary situation, in which some aspects of gonococcal treatment are governed by the 2020 CDC guidelines whereas other aspects are still governed by the 2015 guidelines.

Let's see which aspects of gonorrhea treatment in the following case fall under the 2020 versus the 2015 guidelines.

A 22-year-old college student presents with a 5-day history of fever, joint pain, and rash.

On physical examination, his left knee and right wrist are warm, tender, and swollen to palpation.

He also has a few pustules on his hands and knees.

He says he had unprotected sex when he traveled to Hawaii a month ago.

A nucleic acid amplification (NAAT) test of his urine is positive for Neisseria gonorrhoeae but negative for Chlamydia trachomatis


What is the antibiotic treatment of choice for specifically treating the Neisseria gonorrhoeae infection in this patient?

Answer Options:


cefotaxime plus penicillin

ceftriaxone plus azithromycin


See the Answer:

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