How Does the New Johnson & Johnson Janssen COVID-19 Vaccine Compare to Moderna and Pfizer-BioNTech Vaccines

Andrea Eberly, MD, MS, FAAEMEmergency Medicine, Family Medicine, Guideline Knowledge Check, Internal Medicine, Medical News, Nurse Practitioner, Nursing RN/PN, Pediatric Emergency Medicine, Pediatric Medicine, Personal Education, Physician Assistant, Product News, Urgent Care

Johnson & Johnson COVID-19 Vaccine Guidelines

How Does the Johnson & Johnson COVID-19 Vaccine Differ from Moderna and Pfizer-BioNTech Vaccines?

The CDC just updated their COVID-19 vaccination guidelines to include the Johnson & Johnson Janssen (J/J/Janssen) vaccine.

The just updated CDC Vaccine guidelines include the newly authorized Johnson & Johnson COVID-19 vaccine. According to the Centers of Disease Control and Prevention (CDC), how does the (J/J/Janssen) vaccine compare to other recently authorized COVID-19 vaccines?

Try this review question and find out if you’re following the most current guideline.

Try this review question and find out if you're following the most current guidelines regarding the Johnson & Johnson COVID-19 vaccine and others.

A COVD-19 vaccination hub has access to ordering any one of the 3 COVID-19 vaccines – Moderna, Pfizer-BioNTech, or J/J/Janssen - that are authorized for emergency use in the United States.

A discussion ensues among the leadership tasked with ordering, which vaccine(s) to obtain.


According to recent national guidelines and research papers, which of the following statements is correct about these 3 COVID-19 vaccines?

Answer Options:

All 3 vaccines are nearly 100% effective at preventing death from COVID-19; however, the J/J/Janssen COVID-19 vaccine is less effective (73%) than the Moderna and Pfizer-BioNTech vaccines (95% effective) at preventing hospitalizations due to COVID-19.

Both the Moderna and J/J/Janssen COVID-19 vaccines can be stored in a regular freezer at -25°C and -15°C (-13°F and 5°F), whereas the Pfizer-BioNTech requires super-cold storage.

The J/J/Janssen COVID-19 vaccine remains usable for 12 hours after puncture, whereas Moderna and Pfizer-BioNTech vaccines only remain usable for 6 hours after puncture of the vial.

The Moderna, Pfizer-BioNTech, and J/J/Janssen COVID-19 vaccines all invade host cells to induce intracellular manufacture a piece of SARS-CoV-2 RNA that is displayed on the host's cell surface where it triggers an immune response.

See the Answer:

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