Pediatric ImmunodeficiencyBoard Review Questions of the Week
Pediatric immunodeficiency disorders are thought to affect one in 2,000 children younger than 18 years. In the United States, the most common types of pediatric immunodeficiency disease (primary immunodeficiency disease in children) are antibody disorders, followed by combined B-cell and T-cell disorders, phagocytic defects, and complement disorders.
Antibody, combined B-cell and T-cell, phagocytic, and complement disorders are the most common types of pediatric immunodeficiency disease. Children with these immunodeficiency diseases tend to have bacterial or fungal infections with unusual organisms, or unusually severe and recurrent infections with common organisms. A family history of primary immunodeficiency disease is the strongest predictor of a pediatric immunodeficiency. When an immunodeficiency disease is suspected, initial laboratory screening should include a complete blood count with differential and measurement of serum immunoglobulin and complement levels.
This week's Med-Challenger CME Quick Quiz offers several pediatric immunodeficiency and immunology review questions. Try this sample then head over and take the full quiz and earn CME credit, How's your knowledge of pediatric immunodeficiency?
Try this pediatric immunodeficiency board review sample question...Then try the full quiz and earn CME!
A 5-year-old boy presents for evaluation of recurrent infections of his respiratory, gastrointestinal (GI), and urogenital tracts. GI cultures recently yielded giardiasis.
Allergy testing was positive for immunoglobulin (Ig) G antibodies against cow’s milk.
A blood transfusion when the child was 3 years of age resulted in an anaphylactic reaction.
The only immune testing performed in the past was IgG subclass levels, which are normal.
Today's physical examination is notable for the presence of nonenlarged tonsils.
You also note palpable but small lymph nodes.
In this pediatric immunodeficiency case, what is the most likely underlying immunodeficiency?
Common variable immunodeficiency (CVID)
X-linked agammaglobulinemia (XLA)
See the answer...
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